Tablets/Capsules Fierce Nolvadex/Tamoxifen Citrate US Domestic Shipping 3 Days

slow down or stop the growth of hormone-sensitive tumors.

Tamoxifen is often prescribed for women with estrogen receptor-positive breast cancer, particularly after surgery and radiation. It can be used in both premenopausal and postmenopausal women.

Potential for uterine cancer with long-term use

Tamoxifen is generally well-tolerated, but it is essential to discuss potential risks and benefits with a healthcare provider.

Effective Against Hormone-Receptor-Positive Cancers: Tamoxifen is particularly effective for estrogen receptor-positive (ER+) breast cancers, helping to slow or stop the growth of tumors that rely on estrogen.

Reduces Risk in High-Risk Women:

When used after surgery (adjuvant therapy), tamoxifen has been shown to improve survival rates and reduce recurrence in women treated for early-stage breast cancer.

Tamoxifen can be used in various stages of breast cancer, including early-stage, metastatic, and as a preventive measure.

Although rare, tamoxifen is also used to treat breast cancer in men, especially those with hormone-sensitive tumors.

Cost-Effectiveness:

Tamoxifen (Nolvadex) offers numerous benefits, particularly in treating and preventing hormone-sensitive breast cancer. Its ability to reduce the risk of recurrence and improve survival rates makes it a valuable medication in oncology. However, as with any medication, it is essential to discuss its use, benefits, and potential side effects with a healthcare provider.

Although classed as an estrogen antagonist it should be noted that in some parts of the body tamoxifen actually acts as an estrogen agonist meaning it actually acts in an estrogenic manner as opposed to how most think of it being which is an anti-estrogen. When it acts in an estrogenic fashion in the liver for instance, tamoxifen can increase levels of sex hormone binding globulin (SHGB) which acts to bind to testosterone thus lowering free testosterone in the body. Free testosterone is the amount of unbound testosterone in the system and it is the level of free testosterone which is strongly correlated to the positive effects of high testosterone such as increased muscle mass, strength, and libido.

By lowering free testosterone, tamoxifen has the potential to hurt our bodybuilding gains. This helps to explain why we never hear of people using tamoxifen on a standalone basis (similar to how a testosterone booster is used) and gaining any muscle mass despite the significant rise in testosterone it is capable of producing. Quite simply, a lot of the testosterone rise is cancelled out by the increase in SHGB. Another negative of tamoxifen's action in the liver is its ability to suppress production of the peptide hormone IGF-1. IGF-1 is broken down from growth hormone and is considered to be more potent than growth hormone itself for the purposes of building muscle tissue. High IGF-1 levels make a big contribution to the process of building a better physique and the ability of tamoxifen to suppress IGF-1 levels is another reason why tamoxifen use tends to be disappointing for the purposes of building muscle mass.

In fact, a recent study which showed a rise in total testosterone (they failed to measure free testosterone or levels of SHGB) and a reduction in IGF-1 levels after tamoxifen usage is a significant indicator as to why it can prove disappointing for the building or maintenance of muscle mass.(1,2) The fact that tamoxifen is referred to as an anti-estrogen overlooks the fact that outside of certain tissues it promotes estrogenic effects. A study published in the Journal of Endocrinology(3) showed that long term tamoxifen use increased serum testosterone levels by 50% which is certainly a healthy increase. However, at the same time serum estrogen levels increased by a massive 341%. In fact, in the control group in this study, which only used tamoxifen for a week, estrogen rose after just four days. Considering that the subjects in this trial used tamoxifen at a lower dose of just 10mg it begs the question of what would happen if used at the higher dosage typically seen in bodybuilding circles.

Tamoxifen is of course frequently used to suppress estrogenic action in breast tissue to prevent gynecomastia for which it can work rather well during cycle. It will not totally eliminate the possibility of gyno though especially with those steroids that act in a progesterogenic fashion for which something that lowers prolactin such as the supplement Vitex will be required. Assuming though that your cycle went well and you ran a PCT and you battled through the suppressed sex drive, low IGF-1 levels and low free testosterone levels seen with tamoxifen usage. What happens when you remove tamoxifen? If we consider the study above which shows a profound rise in estrogen in the body during tamoxifen use, its removal is going to create a situation where we now have high estrogen levels in the body and with nothing to stop this estrogen from causing gyno in male bodybuilders. This creates a recipe for the kind of rebound gyno that you often hear people complaining about on bodybuilding forums. Adding insult to injury, high estrogen levels are suppressive in their own right which can cause delayed progress in the gym when coming off tamoxifen use..

Carcinogenic action - Tamoxifen has been shown in several studies 4,5,6) to increase the risk of cancer and is listed as a known carcinogen by the American Cancer Society. A 2006 study in The Lancet showed it increased mortality rate in women using tamoxifen. Studies in rats (7) add further weight to the argument supporting tamoxifen's carcinogenic potential with up to 80% of animals developing malignant tumours.

- Tamoxifen has been studied for its effects on liver for some time with it being linked to fatty liver in women (8) as well as showing an increased likelihood in the formation of liver cancer.

- Tamoxifen is acutely toxic to the eyes with more than one report on a bodybuilding forum showing a user who irreversibly damaged their eyesight. Studies (9,10) support the notion that tamoxifen can contribute to increasing susceptibility to cataracts.

- Tamoxifen usage is recognised as increasing the risk of blood clotting which if it occurs in a major artery or cardiac tissue can potentially be life threatening. For bodybuilders whose blood pressure may be high it makes tamoxifen use doubly dangerous.

- As previously noted the negative impact on free testosterone levels of tamoxifen can cause users to fail to experience the effects associated with elevated testosterone including libido. Compared to other compounds which increase testosterone, tamoxifen users tend to report poorer libido. In addition, the adverse effect on blood clots means it can make erectile dysfunction more likely as well. It is for this reason that many users will employ a testosterone booster in PCT to help address these shortcomings of tamoxifen usage.

- Perhaps the most common complaint of all from bodybuilders using tamoxifen or other SERM's during PCT is they cause unbearable mood swings with frequent reports of tearfulness, and depression occurring among bodybuilders. While not everyone gets this it is notable that these effects don't get reported to anywhere the same extent with other PCT products making it feasible that this occurs as a consequence of the rise in serum estrogen seen during tamoxifen use.

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